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2024 Vol.51, Issue 2 Preview Page

Food & Chemistry

Effect of cordycepin-enriched Cordyceps militaris L. extract powder on alcohol degradation and hepatoprotection in mice alcohol model
Ju-Hye Kim12†
,
Heejin Park2†
,
Mun-Hyoung Bae3
,
Youngha Seo3
,
Eun-Young Gu2
,
Taek-Keun Oh1*
,
Byoung-Seok Lee2*
1Department of Bio-Environmental Chemistry, College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, Korea
2Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), Daejeon 34114, Korea
3Functional Materials Research Team, Rpbio Research Institute, Rpbio Co., Ltd., Suwon 16229, Korea
*Corresponding Author
*Corresponding Author
†These authors equally contributed to this study as first author.
1 June 2024. pp. 169-178
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Abstract

Cordyceps militaris L. (C. militaris) has been traditionally used as tonic medicine for metabolic syndrome. Cordycepin, has been reported with immunomodulatory, antitumor, and hepatoprotective effect, is the main extract from C. militaris. This study was conducted to evaluate the alcohol degradation and hepatoprotective effect of cordycepin-enriched C. militaris extract (CM) powder in chronic and binge ethanol (ethanol Lieber-DeCarli diet)-fed male C57BL/6 Mice. Cordycepin-enriched C. militaris extract powder was orally administered once daily at dose levels of 0, 125, 250, and 500 mg·kg-1·day-1 for 16 days. For evaluating alcohol degradation, ethanol concentration and alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity were measured in serum. Serum ethanol (EtOH) concentration was decreased at CM treated groups, and the activities of ADH and ALDH were increased dose-dependently at CM treated groups compare to EtOH model group. In clinical chemistry, the values of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were lower in CM treated groups than those in EtOH model group. Additionally, absolute and relative (to body weight) liver weights were statistically decreased in the CM treated groups compared to the EtOH model group. In conclusion, our study showed that cordycepin-enriched C. militaris extract powder exhibits hepatoprotective effect by upregulating the ADH and ALDH enzyme in an alcoholic liver disease model.

Keywords
alcohol
alcohol-induced hepatic steatosis
Cordyceps militaris extract
liver damage
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Information
  • Publisher :Institute of Agricultural Science, Chungnam National University
  • Publisher(Ko) :충남대학교 농업과학연구소
  • Journal Title :Korean Journal of Agricultural Science
  • Journal Title(Ko) :농업과학연구
  • Volume : 51
  • No :2
  • Pages :169-178
  • Received Date : 2024-03-20
  • Revised Date : 2024-04-01
  • Accepted Date : 2024-05-02
  • DOI :https://doi.org/10.7744/kjoas.510207
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