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2024 Vol.51, Issue 2 Preview Page

Food & Chemistry

Hepatoprotective effect of cordycepin-enriched Cordyceps militaris extract powder on high fat diet-induced hepatic steatosis in obese (ob/ob) mice
Ju-Hye Kim12†
,
Heejin Park2†
,
Mun-Hyoung Bae3
,
Youngha Seo3
,
Eun-Young Gu2
,
Taek-Keun Oh1*
,
Byoung-Seok Lee2*
1Department of Bio-Environmental Chemistry, College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, Korea
2Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), Daejeon 34114, Korea
3Functional Materials Research Team, Rpbio Research Institute, Rpbio Co., Ltd., Suwon 16229, Korea
*Corresponding Author
*Corresponding Author
†These authors equally contributed to this study as first author.
1 June 2024. pp. 159-167
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Abstract

Herbal medicinal mushroom Cordyceps militaris has been traditionally used as tonic medicine for metabolic syndrome. Cordycepin, main extract of C. militaris, has been reported with immunomodulatory, anticancer, and hepatoprotective effects. This study was conducted to evaluate the potential hepatoprotective effect of cordycepin-enriched Cordyceps militaris, against high fat diet (HFD)-induced hepatic steatosis (HS) in male obese (ob/ob) mice. HFD was provided to ob/ob mice ad libitum (except negative control). Cordycepin-enriched C. militaris extract powder (CM) was orally administered once daily at dose levels of 0, 125, 250, and 500 mg·kg-1 for 4 weeks. During the study, body weight gain was statistically increased in all HFD fed groups compared to negative control, but body weight gain in CM 500 mg·kg-1 treated group shows a low tendency compared to HS model group. In organ weights, absolute and relative weights (to body weight) in liver and perirenal adipose tissue were increased in all HFD treated groups except CM 500 mg·kg-1 treated group compared to the negative control. In clinical chemistry, serum glucose and total cholesterol levels in CM 250 and/or 500 mg·kg-1 treated groups were lower than HS model group. In microscopical examination, hepatocyte vacuolation with macrovesicles in HS model group was increased compared to negative control, but this finding was decreased in CM 500 mg·kg-1 treated group compared to HS model group. In this study, CM exhibited hepatoprotective effects against hepatic steatosis at mg·kg-1 in ob/ob mice.

Keywords
Cordyceps militaris extract
high fat diet-induced hepatic steatosis
liver damage
ob/ob mice
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Information
  • Publisher :Institute of Agricultural Science, Chungnam National University
  • Publisher(Ko) :충남대학교 농업과학연구소
  • Journal Title :Korean Journal of Agricultural Science
  • Journal Title(Ko) :농업과학연구
  • Volume : 51
  • No :2
  • Pages :159-167
  • Received Date : 2024-03-20
  • Revised Date : 2024-04-01
  • Accepted Date : 2024-05-02
  • DOI :https://doi.org/10.7744/kjoas.510206
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