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2024 Vol.51, Issue 2 Preview Page

Food & Chemistry

Evaluation of liver function using Cordyceps militaris extract powder in Sprague-Dawley rat with acute hepatic injury induced by dimethylnitrosamine
Heejin Park1†
,
Ju-Hye Kim12†
,
Mun-Hyoung Bae3
,
Youngha Seo3
,
Eun-Young Gu1
,
Taek-Keun Oh2*
,
Byoung-Seok Lee1*
1Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), Daejeon 34114, Korea
2Department of Bio-Environmental Chemistry, College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, Korea
3Functional Materials Research Team, Rpbio Research Institute, Rpbio Co., Ltd., Suwon 16229, Korea
*Corresponding Author
*Corresponding Author
†These authors equally contributed to this study as first author.
1 June 2024. pp. 147-158
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Abstract

Hepatic fibrosis refers to the scarring of liver tissue, often resulting from chronic liver injury or inflammation. It is characterized by excessive deposition of extracellular matrix proteins, impairing liver function and potentially progressing to cirrhosis if left untreated. To improve the liver functions, Cordyceps militaris, a species of parasitic fungus known for its medicinal properties, is used in the form of extract. It has been traditionally used in Chinese medicine to boost energy, improve stamina, and support overall health. In this study, we investigated the hepatoprotective effects of Cordyceps militaris extract powder in a liver injury model induced by hepatic fibrosis. Sprague-Dawley (SD) rats were administered Dimethylnitrosamine (DMN) to induce liver injury, and the hepatoprotective effects of Cordyceps militaris extract powder intake were assessed by comparing changes in liver enzyme levels and histological observations. Rats injected with DMN were orally administered Cordyceps militaris extract powder at doses of 0, 125, 250, and 500 mg·kg-1·day-1 for three weeks. After three weeks of treatment, no significant differences were observed in hematological, clinical chemical, organ weight, gross examination, or microscopic examination between the DMN-alone group and the Cordyceps militaris extract powder-treated group. In conclusion, hepatoprotective effects against DMN-induced liver injury in SD rats treated with Cordyceps militaris extract powder were not observed under this study condition.

Keywords
Cordyceps militaris extract
dimethylnitrosamine (DMN)
hepatic fibrosis
liver damage
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Information
  • Publisher :Institute of Agricultural Science, Chungnam National University
  • Publisher(Ko) :충남대학교 농업과학연구소
  • Journal Title :Korean Journal of Agricultural Science
  • Journal Title(Ko) :농업과학연구
  • Volume : 51
  • No :2
  • Pages :147-158
  • Received Date : 2024-03-20
  • Revised Date : 2024-04-01
  • Accepted Date : 2024-05-02
  • DOI :https://doi.org/10.7744/kjoas.510205
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